Sowin, Thomas J: search on Z-Library

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1

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Gaoquan Li, Lisa A. Hasvold, Zhi-Fu Tao, Gary T. Wang, Stephen L. Gwaltney II, Jyoti Patel, Peter Kovar, Robert B. Credo, Zehan Chen, Haiying Zhang, Chang Park, Hing L. Sham, Thomas Sowin, Saul H. Ros

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

2

Synthesis of 2-Substituted (±)-(2 R, 3 R, 5 R )-Tetrahydrofuran-3,5-dicarboxylic Acid Derivatives †

Wang, Gary T., Wang, Sheldon, Chen, Yuanwei, Gentles, Robert, Sowin, Thomas

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 63 KB

english, 2001

3

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Yunsong Tong, Kent D. Stewart, Sheela Thomas, Magdalena Przytulinska, Eric F. Johnson, Vered Klinghofer, Joel Leverson, Owen McCall, Niru B. Soni, Yan Luo, Nan-horng Lin, Thomas J. Sowin, Vincent L. G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 490 KB

english, 2008

4

Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors

Tao, Zhi-Fu, Wang, Le, Stewart, Kent D., Chen, Zehan, Gu, Wendy, Bui, Mai-Ha, Merta, Philip, Zhang, Haiying, Kovar, Peter, Johnson, Eric, Park, Chang, Judge, Russell, Rosenberg, Saul, Sowin, Thomas, L

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 463 KB

english, 2007

5

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Lisa A. Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen, Wen-Zhen Gu, Philip J. Merta, John Xue, Peter Kovar, Haiying Zhang, Chang Park, Thomas J. Sowin, Saul H. Rosenberg, Nan-Horng L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008

6

Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics

Zhi-Fu Tao, Zehan Chen, Mai-Ha Bui, Peter Kovar, Eric Johnson, Jennifer Bouska, Haiying Zhang, Saul Rosenberg, Thomas Sowin, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 304 KB

english, 2007

7

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors

Gaoquan Li, Zhi-Fu Tao, Yunsong Tong, Magdalena K. Przytulinska, Peter Kovar, Philip Merta, Zehan Chen, Haiying Zhang, Thomas Sowin, Saul H. Rosenberg, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 181 KB

english, 2007

8

Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation

M. Robert Leanna, Thomas J. Sowin, Howard E. Morton

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 280 KB

english, 1992

9

Solid-Phase Synthesis of Benzoxazoles from 3-Nitrotyrosine

Beebe, Xenia, Wodka, Dariusz, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

10

Enantioselective synthesis of the 1.beta.-methylcarbapenems via cycloaddition of 3-siloxypentadiene and 4-acetoxyazetidinone

Sowin, Thomas J., Meyers, A. I.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 439 KB

english, 1988

11

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 317 KB

english, 2005

12

Synthesis of Macrocyclic Urea Kinase Inhibitors

Tao, Zhi-Fu, Sowin, Thomas, Lin, Nan-Horng

Journal:

Year:

2007

Language:

english

File:

PDF, 97 KB

english, 2007

13

Purification of HTOS Libraries by Supercritical Fluid Chromatography

Hochlowski, Jill, Olson, Jeff, Pan, Jeff, Sauer, Daryl, Searle, Philip, Sowin, Thomas

Journal:

Journal of Liquid Chromatography & Related Technologies

Year:

2003

Language:

english

File:

PDF, 731 KB

english, 2003

14

Encyclopedia of Reagents for Organic Synthesis || Crotonaldehyde

Sowin, Thomas J.

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

15

Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones.

Rolf E. Swenson, Thomas J. Sowin, Henry Q. Zhang

Journal:

Year:

2003

File:

PDF, 218 KB

2003

16

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Zhi-Fu Tao, Gaoquan Li, Yunsong Tong, Kent D. Stewart, Zehan Chen, Mai-Ha Bui, Philip Merta, Chang Park, Peter Kovar, Haiying Zhang, Hing L. Sham, Saul H. Rosenberg, Thomas J. Sowin, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 330 KB

english, 2007

17

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities

Wang, Gary T., Li, Gaoquan, Mantei, Robert A., Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L., Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 269 KB

english, 2005

18

A facile synthesis of chiral bicyclic lactams utilized in the formation of chiral quaternary carbon compounds

Meyers, A. I., Lefker, Bruce A., Sowin, Thomas J., Westrum, Larry J.

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 572 KB

english, 1989

19

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

Zehan Chen, Zhan Xiao, Wen-zhen Gu, John Xue, Mai H. Bui, Peter Kovar, Gaoquan Li, Gary Wang, Zhi-Fu Tao, Yunsong Tong, Nan-Horng Lin, Hing L. Sham, Jean Y. J. Wang, Thomas J. Sowin, Saul H. Rosenberg

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 1.69 MB

english, 2006

20

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Gary T. Wang, Xilu Wang, Weibo Wang, Lisa A. Hasvold, Gerry Sullivan, Charles W. Hutchins, Steve O’Conner, Robert Gentiles, Thomas Sowin, Jerry Cohen, Wen-Zhen Gu, Haiying Zhang, Saul H. Rosenberg, Hi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

21

Design, preparation and performance of a phthalide-based chiral stationary phase

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 663 KB

english, 1987

22

Preparative separation of enantiomers by flash chromatography

William H. Pirkle, Athanasios Tsipouras, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1985

Language:

english

File:

PDF, 204 KB

english, 1985

23

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Xiao, Zhan, Xue, John, Gu, Wen-Zhen, Bui, Mai, Li, Gaoquan, Tao, Zhi-Fu, Lin, Nan-Horng, Sowin, Thomas J., Zhang, Haiying

Journal:

Year:

2008

Language:

english

File:

PDF, 882 KB

english, 2008

24

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Irini Akritopoulou-Zanze, Daniel H. Albert, Peter F. Bousquet, George A. Cunha, Christopher M. Harris, Maria Moskey, Jurgen Dinges, Kent D. Stewart, Thomas J. Sowin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

25

Synthesis of Substituted Quinolines Using the Dianion Addition of N -Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones

Swenson, Rolf E., Sowin, Thomas J., Zhang, Henry Q.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

26

Amino-Substituted Heterocycles as Isosteres of trans-Cinnamides: Design and Synthesis of Heterocyclic Biaryl Sulfides as Potent Antagonists of LFA-1/ICAM-1 Binding.

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Year:

2005

File:

PDF, 17 KB

2005

27

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Clarence J. Maring, Dale J. Kempf, Warren M. Kati, Vincent Stoll, Kent D. Stewart, Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

28

A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen

Zhi-Fu Tao, Thomas J. Sowin, Nan-Horng Lin

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

29

Correlation of the circular dichroic spectra of 3-arylphthalides with absolute configuration and conformation

Pirkle, William H., Sowin, Thomas J., Salvadori, Piero, Rosini, Carlo

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 536 KB

english, 1988

30

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

Zhan Xiao, John Xue, Dimitri Semizarov, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 985 KB

english, 2005

31

Solid-Phase Organic Synthesis. Volume 1 Edited by Anthony W. Czarnik. John Wiley & Sons, New York. 2001. viii + 164 pp. 16 × 23.5 cm. ISBN 0-471-31484-6. $69.95.

Sowin, Thomas J.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 14 KB

english, 2001

32

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Xiao, Zhan, Xue, John, Sowin, Thomas J, Rosenberg, Saul H, Zhang, Haiying

Journal:

Year:

2004

Language:

english

File:

PDF, 359 KB

english, 2004

33

Application of Base Cleavable Safety Catch Linkers to Solid Phase Library Production

Wade, Warren S., Yang, Fan, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

34

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Wang, Gary T., Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 457 KB

english, 2001

35

Encoding of Combinatorial Chemistry Libraries by Fluorine-19 NMR

Hochlowski, Jill E., Whittern, David N., Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

1999

Language:

english

File:

PDF, 57 KB

english, 1999

36

Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis Edited by Peter Wipf. John Wiley & Sons, Chichester, West Sussex, England. 2005. xi + 380 pp. 22 × 29 cm. ISBN 0-470-86298-X. $140.00.

Sowin, Thomas J.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 26 KB

english, 2005

37

Direct liquid chromatographic separation of phthalide enantiomers

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 686 KB

english, 1987

38

Encyclopedia of Reagents for Organic Synthesis || Acetaldehyde

Sowin, Thomas J.

Year:

2001

Language:

english

File:

PDF, 65 KB

english, 2001

39

Synthesis and separation of diastereomeric imino alcohol derivatives of chiral phthalides: a method for assignment of phthalide absolute configurations

Pirkle, William H., Sowin, Thomas J.

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 1003 KB

english, 1987

40

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Zhi-Fu Tao, Gaoquan Li, Yunsong Tong, Zehan Chen, Philip Merta, Peter Kovar, Haiying Zhang, Saul H. Rosenberg, Hing L. Sham, Thomas J. Sowin, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 443 KB

english, 2007

41

Solid phase synthesis of ureas of secondary amines via carbamoyl chloride

Gary T. Wang, Yuanwei Chen, Sheldon Wang, Richard Sciotti, Thomas Sowin

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 174 KB

english, 1997

42

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

Kempf, Dale J., Sowin, Thomas J., Doherty, Elizabeth M., Hannick, Steven M., Codavoci, LynnMarie, Henry, Rodger F., Green, Brian E., Spanton, Stephen G., Norbeck, Daniel W.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 1.26 MB

english, 1992

43

An efficient enantioselective synthesis of the carbapenam-2-one system. An approach to (+)-thienamycin and related carbapenems

A.I. Meyers, Thomas J. Sowin, Stefan Scholz, Yasutsugu Ueda

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 215 KB

english, 1987

44

Solid-Phase Synthesis of Macrolide Analogues

Akritopoulou-Zanze, Irini, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

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